The Effect of Yiqi Huoxue Tongluo Decoction on Spinal Cord Microglia Activation and ASK1-MKK3-p38 Signal Pathway in Rats with Diabetic Neuropathic Pain.
Fanjing WangHeyong TangJunlong MaLianzhi ChengYixuan LinJindong ZhaoGuo-Ming ShenZhao-Hui FangAijuan JiangPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
Diabetic neuropathic pain (DNP) is one of the most common chronic peripheral neuropathies in diabetes mellitus (DM). Objective . To observe the underlying mechanism of the effects of Yiqi Huoxue Tongluo Decoction (YQHX) on DNP rats. Methods . SD rats were intraperitoneally injected with 35 mg/kg streptozotocin (STZ) to prepare DNP models and were treated with YQHX for 8 weeks. Results . Studies have shown that the drug restores some levels of MWT, TWL, and MNCV, downregulates the levels of inflammatory factors IL-6, IL-1 β , and TNF- α , downregulates the levels of ASK1-MKK3-p38, and weakens the level of OX42 activation. Conclusion . Yiqi Huoxue Tongluo Decoction can relieve DNP by affecting the activity of spinal cord microglia and the ASK1-MKK3-p38 signaling pathway, thereby reducing the central sensitization caused by the inflammatory response of DNP rats.
Keyphrases
- neuropathic pain
- spinal cord
- spinal cord injury
- inflammatory response
- signaling pathway
- type diabetes
- rheumatoid arthritis
- oxidative stress
- high fat diet
- emergency department
- metabolic syndrome
- wound healing
- lipopolysaccharide induced
- glycemic control
- epithelial mesenchymal transition
- adipose tissue
- pi k akt
- insulin resistance
- electronic health record