Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction.
Vineet AgrawalJonathan A KropskiJason J GokeyElizabeth KobeckMatthew MurphyKatherine T MurrayNiki L FortuneChristy S MooreDavid F MeoliKen MonahanYan Ru SuThomas BlackwellDeepak K GuptaMegha H TalatiSanthi GladsonErica J CarrierJames D WestAnna R HemnesPublished in: bioRxiv : the preprint server for biology (2023)
Our study demonstrated that a well-accepted model of HFpEF recapitulates features of pulmonary vascular remodeling commonly seen in patients with HFpEF, and we identified myeloid cell derived IL1β as an important contributor to PH in HFpEF.