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High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia.

Daniel Uricoechea PatiñoAndrew R CollinsOscar Julián Romero GarcíaGustavo Santos VecinoJosé Vicente Rodríguez CuencaJaime E BernalEscilda Benavides BenítezSaray Vergara MuñozIgnacio Briceño Balcázar
Published in: Genes (2023)
The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.
Keyphrases
  • mitochondrial dna
  • copy number
  • endothelial cells
  • genome wide
  • genetic diversity
  • oxidative stress
  • african american
  • dna methylation
  • gene expression
  • electronic health record
  • bone loss
  • artificial intelligence