A new clustering method identifies multiple sclerosis-specific T-cell receptors.

Fumie Hayashi Noriko IsobeJacob GlanvilleTakuya MatsushitaGuzailiayi MaimaitijiangShoko FukumotoMitsuru Watanabe Katsuhisa Masaki Jun-Ichi Kira

Published in: Annals of clinical and translational neurology (2021)

High TCRα/TCRβ diversity, regardless of age, is characteristic of MS. Association of a CMV-recognizing TCR with mild disability indicates CMV's protective role in HLA-DRB1*04:05-positive MS.

Keyphrases

multiple sclerosis
regulatory t cells
white matter
mass spectrometry
ms ms
genome wide
dendritic cells
gene expression
immune response