Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.

Eva Roy-ChowdhuryNicolas Brauns Alexandra HelmkeJohannes NordlohneJan Hinrich BräsenJessica SchmitzJulia VolkmannSusanne V FleigKristina Kusche-VihrogHermann HallerSibylle von Vietinghoff

Published in: Cardiovascular research (2022)

By demonstrating endothelial proatherosclerotic gene regulation in direct contact with CD16+ monocytes, in part via cellular CX3CR1-CX3CL1 interaction, our data delineate a mechanism how this celltype can increase cardiovascular risk.

Keyphrases

endothelial cells
dendritic cells
high glucose
electronic health record
nk cells
big data
machine learning
induced pluripotent stem cells
data analysis
deep learning