Parkinson disease clinical subtypes: key features & clinical milestones.
Meghan C CampbellPeter S MyersAlexandra J WeigandErin R FosterNigel J CairnsJoshua J JacksonChristina N Lessov-SchlaggarJoel S PerlmutterPublished in: Annals of clinical and translational neurology (2020)
Psychiatric and cognitive features, rather than motor deficits, distinguish clinical PD subtypes and predict greater risk of subsequent dementia and mortality. These results emphasize the value of multi-domain assessments to better characterize clinical variability in PD. Further, differences in dementia and mortality rates demonstrate the prognostic utility of PD subtypes.