Cysteinyl leukotriene D4 (LTD4) promotes airway epithelial cell inflammation and remodelling.
Neeraj DholiaGurupreet S SethiAmarjit S NauraUmesh Chand Singh YadavPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)
The results suggest that LTD4 could induce inflammatory response in human airway epithelial cell by activating NALP3 inflammasome. LTD4 could further promote airway epithelial cells' remodelling through TGF-β/smad2/3-mediated pathway. Our in vivo results suggested that obesity predisposed the OVA challenged mice to develop lung inflammation and remodelling akin to asthma-like phenotypes during obesity.
Keyphrases
- high fat diet induced
- inflammatory response
- insulin resistance
- oxidative stress
- metabolic syndrome
- weight loss
- transforming growth factor
- type diabetes
- endothelial cells
- weight gain
- chronic obstructive pulmonary disease
- signaling pathway
- lipopolysaccharide induced
- lung function
- induced pluripotent stem cells
- adipose tissue
- skeletal muscle
- body mass index
- immune response
- allergic rhinitis
- cystic fibrosis
- wild type