Mood Disorders and Aggressive Traits Mediate Effects of Reported Childhood Adversity on Suicide Attempt Risk.
Jessica M RabbanySteven EllisAllison MettsAinsley BurkeDavid A BrentNadine MelhemStephen MarcottJ John MannPublished in: Archives of suicide research : official journal of the International Academy for Suicide Research (2022)
Amelioration of aggressive traits and treatment of mood disorders in CA-exposed offspring of a parent with a mood disorder may prevent future suicide attempts and may reduce the risk of mood disorder. Familial factors influence the impact of childhood physical abuse but not sexual abuse. HIGHLIGHTSChildhood Adversity (CA) predicted future mood disorder and aggression severity.Depression and aggression mediate the relationship between CA and suicide attempts.When one mediator is present, the presence of the other does not increase the hazard.Between family variation contributed much more to suicidal behavior outcomes relative to the effect of physical abuse, but sexual abuse contributed to suicidal outcomes more than family variation.
Keyphrases
- bipolar disorder
- sleep quality
- depressive symptoms
- early life
- physical activity
- mental health
- genome wide
- current status
- high fat diet
- type diabetes
- gene expression
- adipose tissue
- dna methylation
- early onset
- intimate partner violence
- young adults
- childhood cancer
- skeletal muscle
- replacement therapy
- combination therapy