The effect of chemotherapy on olfactory function and mucociliary clearance.

Fakih Cihat EravcıGökhan UçarKürşat Murat ÖzcanMustafa ÇolakYakup ErgünYusuf AçıkgözAykut IkincioğullarıDoğan UncuHacı Hüseyin Dere

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)

Chemotherapy impairs both the mucociliary clearance and olfactory function in cancer patients. This might reflect the collective negative effect of chemotherapy on olfactory function, not only through the neurocytotoxic effect but also the cytotoxic effect on the nasal mucosa. In addition, the reduction in olfactory threshold and total olfactory function scores was seen to be more profound in younger patients, which could have been due to higher initial scores.

Keyphrases

locally advanced
end stage renal disease
ejection fraction
squamous cell carcinoma
radiation therapy
peritoneal dialysis
intellectual disability
autism spectrum disorder
chemotherapy induced
chronic rhinosinusitis