Uridine diphosphate glucuronosyl transferase 1A (UGT1A1) promoter polymorphism in young patients with sickle cell anaemia: report of the first cohort study from Nigeria.

Oladele Simeon OlatunyaDulcineia Martins AlbuquerqueGaniyu Olusola AkanbiOlufunso Simisola AduayiAdekunle Bamidele TaiwoOpeyemi Ayodeji FaboyaTolorunju Segun KayodeDaniela Pinheiro LeonardoAdekunle AdekileFernando Ferreira Costa

Published in: BMC medical genetics (2019)

This study highlights the contribution of UGT1A1 polymorphisms, a non-globin genetic factor, to the laboratory and clinical manifestations of young Nigerian SCA patients for the first time. It also shows that children with co-inheritance of low UGT1A1 (TA) n affinity genotypes may be at risk of gallstone, hence the need to follow them up.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
dna methylation
middle aged
gene expression
peritoneal dialysis
prognostic factors
mitochondrial dna
transcription factor
genome wide
copy number
patient reported