Controlling SpyTag/SpyCatcher Reactivity via Redox-Gated Conformational Restriction.

Wen-Hao WuJingjing WeiWen-Bin Zhang

Published in: ACS macro letters (2018)

Herein, we report that the reactivity of genetically encoded SpyTag/SpyCatcher chemistry can be manipulated via redox-gated conformational restriction, which facilitates the preparation of all-protein-based hydrogel with latent reactive sites for subsequent covalent functionalization.

Keyphrases

molecular dynamics
molecular dynamics simulations
single molecule
drug delivery
electron transfer
protein protein
molecularly imprinted
drug discovery
solid phase extraction