Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions.
Fumiaki MoriMari TadaTomoya KonYasuo MikiKunikazu TanjiHidekachi KurotakiMasahiko TomiyamaTomohiko IshiharaOsamu OnoderaAkiyoshi KakitaKoichi WakabayashiPublished in: Acta neuropathologica communications (2019)
The present findings indicate that pTDP-43 aggregates in skeletal and cardiac muscle are a myogenic pathological marker in multiple diseases including ALS.