In vitro antiplasmodial activity and toxicological profile of extracts, fractions and chemical constituents of leaves and stem bark from Dacryodes edulis (Burseraceae).

Kevine Johane Jumeta DongmoMariscal Brice Tchatat TaliYannick Stéphane Fotsing FongangPierre Leonel K Tafokeu TaguimjeuDonald Ulrich Kenou KaghoGabin Thierry BitchagnoBruno Ndjakou LentaFabrice Fekam BoyomNorbert SewaldSilvère Augustin Ngouela

Published in: BMC complementary medicine and therapies (2023)

This work highlights the good in vitro antiplasmodial potency of the hydroethanolic extract of the leaves of this plant and that of two isolated constituents (3,3',4-tri-O-methylellagic acid and ethylgallate) from the plant. These biological results support the use of D. edulis in traditional medicine against malaria.

Keyphrases

essential oil
oxidative stress
cell wall
plasmodium falciparum
anti inflammatory
oxide nanoparticles