Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and its Links to Genetic Risk.

Armin IrajiJ ChenN LewisA FaghiriZ FuO AgcaogluP KochunovB M AdhikariD H MathalonG D PearlsonF MacciardiA PredaT G M van ErpJ R BustilloC M Díaz-CanejaP Andrés-CamazónM DhamalaT AdaliV D Calhoun

Published in: bioRxiv : the preprint server for biology (2023)

Our method can effectively capture spatially dynamic networks, detect nuanced SZ effects, and reveal the intricate relationship of dynamic information to genomic data. The results also underscore the potential of dynamic spatial dependence and weak connectivity in the clinical landscape.

Keyphrases

genome wide
single cell
healthcare
electronic health record
gene expression
multiple sclerosis
white matter
big data
resting state
climate change
blood brain barrier
data analysis