Bone Regeneration Induced by Strontium Folate Loaded Biohybrid Scaffolds.
Marcela Martín-Del-CampoJosé G SampedroMaría Lisseth Flores-CedilloRaul Rosales-IbañezLuis RojoPublished in: Molecules (Basel, Switzerland) (2019)
Nowadays, regenerative medicine has paid special attention to research (in vitro and in vivo) related to bone regeneration, specifically in the treatment of bone fractures or skeletal defects, which is rising worldwide and is continually demanding new developments in the use of stem cells, growth factors, membranes and scaffolds based on novel nanomaterials, and their applications in patients by using advanced tools from molecular biology and tissue engineering. Strontium (Sr) is an element that has been investigated in recent years for its participation in the process of remodeling and bone formation. Based on these antecedents, this is a review about the Strontium Folate (SrFO), a recently developed non-protein based bone-promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current therapies for bone diseases.
Keyphrases
- bone regeneration
- tissue engineering
- stem cells
- end stage renal disease
- ejection fraction
- newly diagnosed
- healthcare
- chronic kidney disease
- drug delivery
- physical activity
- peritoneal dialysis
- prognostic factors
- bone mineral density
- patient reported outcomes
- cancer therapy
- body composition
- bone marrow
- high resolution
- small molecule
- patient reported
- replacement therapy