Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia.
Karen Thudium MuellerEdward WaldronStephan A GruppJohn E LevineTheodore W LaetschMichael A PulsipherMichael W BoyerKeith J AugustJason HamiltonRakesh AwasthiAndrew M SteinDenise SickertAbhijit ChakrabortyCarl H JuneLori TomassianSweta S ShahMimi LeungTetiana TaranPatricia A WoodShannon L MaudePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Response to tisagenlecleucel was associated with increased expansion across a wide dose range. These results highlight the importance of cellular kinetics in understanding determinants of response to chimeric antigen receptor T-cell therapy.