Sustained microglial activation in the area postrema of collagen-induced arthritis mice.
Takayuki MatsushitaKazuhiro OtaniYohsuke OtoYukari TakahashiDaitaro KurosakaFusao KatoPublished in: Arthritis research & therapy (2021)
Our findings demonstrate that microglia in the AP can sustain their activated state during persistent autoimmune arthritis, which suggests that chronic inflammation, such as RA, may affect microglia in brain regions lacking a BBB and have various neural consequences.
Keyphrases
- rheumatoid arthritis
- inflammatory response
- neuropathic pain
- drug induced
- oxidative stress
- diabetic rats
- lipopolysaccharide induced
- lps induced
- high glucose
- disease activity
- blood brain barrier
- multiple sclerosis
- resting state
- spinal cord
- spinal cord injury
- high fat diet induced
- ankylosing spondylitis
- interstitial lung disease
- functional connectivity
- cerebral ischemia
- wound healing
- insulin resistance
- tissue engineering