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Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival.

Peter GeorgesonRobert S SteinfelderTabitha A HarrisonBernard J PopeSyed H ZaidiConghui QuYi LinJihoon E JooKhalid MahmoodMark ClendenningRomy WalkerElom K AglagoSonja I BerndtHermann BrennerPeter T CampbellYin CaoAndrew T ChanJenny Chang-ClaudeNiki DimouKimberly F DohenyDavid A DrewJane C FigueiredoAmy J FrenchSteven GallingerMarios GiannakisGraham G GilesEllen L GoodeStephen B GruberAndrea GsurMarc J GunterSophia HarlidMichael HoffmeisterLi HsuWen-Yi HuangJeroen R HuygheJoAnn E MansonVictor MorenoNeil MurphyRami NassirChristina C NewtonJonathan A NowakMireia Obón-SantacanaShuji OginoRish K PaiNikos PapadimitrouJohn D PotterRobert E SchoenMingyang SongWei SunAmanda E TolandQuang M TrinhKostas TsilidisTomotaka UgaiCaroline Y UmFinlay A MacraeChristophe RostyThomas J HudsonIngrid M WinshipAmanda I PhippsMark A JenkinsUlrike PetersDaniel D Buchanan
Published in: medRxiv : the preprint server for health sciences (2023)
SBS88-positivity, a biomarker of colibactin-induced DNA damage, can identify a novel subtype of CRC characterized by recurrent somatic mutations, copy number alterations and better survival. These findings provide new insights for treatment and prevention strategies for this subtype of CRC.
Keyphrases
  • copy number
  • mitochondrial dna
  • dna damage
  • genome wide
  • dna methylation
  • free survival
  • oxidative stress
  • high glucose
  • diabetic rats
  • dna repair