A Randomised Controlled Trial of Nasal Immunisation with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge.
Helen HillElena MitsiElissavet NikolaouAnnie BlizardSherin PojarAshleigh HowardAngela Hyder-WrightJack DevinJesus ReinéRyan E RobinsonCarla SolórzanoSimon P JochemsTinashe Kenny-NyazikaElisa Ramos-SevillanoCaroline M WeightChris MyerscoughDaniella McLenaghanBen MortonEmily GibbonsMadlen FarrarVictoria RandlesHassan BurhanTao ChenAdam D ShandlingJoe J CampoRobert Simon HeydermanStephen B GordonJeremy S BrownAndrea M CollinsDaniela M FerreiraPublished in: American journal of respiratory and critical care medicine (2023)
Nasal colonisation with genetically modified live attenuated Spn was safe and induced protection against recolonisation, suggesting nasal adminstration of live attenuated Spn could be an effective stategy for preventing pneumococcal infections.