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An efficient Perkin synthesis of 13 C-labelled cinnamic acids from acetic acid as the source of the rare isotope.

Dominik LenzBenjamin KoeppePeter M TolstoyHans-Heinrich Limbach
Published in: Journal of labelled compounds & radiopharmaceuticals (2020)
A variation of the Perkin reaction using a nonenolizable anhydride as the condensation agent allows for the effective conversion of valuable carboxylic acids to the corresponding cinnamates.
Keyphrases
  • mass spectrometry
  • liquid chromatography