Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Pia Gattinger Katarzyna NiespodzianaKarin StiasnySabina SahanicInna TulaevaKristina BorochovaYulia DorofeevaThomas SchledererThomas SonnweberGerhard HoferRenata KissBernhard KratzerDoris TrapinPeter A TauberArno RottalUlrike KörmöcziMelanie FeichterMilena WeberMargarete Focke-TejklJudith Löffler-RaggBernhard MühlAnna KropfmüllerWalter KellerFrank StolzRainer HenningIvan TancevskiElisabeth Puchhammer-StöcklWinfried F Pickl Rudolph Valenta

Published in: Allergy (2021)

These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

Keyphrases

sars cov
respiratory syndrome coronavirus
molecular dynamics
molecular dynamics simulations
binding protein
single molecule
dengue virus
dna binding
zika virus
aedes aegypti