Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.
Jonas GhouseVinicius TraganteAyesha MuhammadGustav AhlbergMorten W SkovDan M RodenIngileif JónsdóttirLaura AndreasenPia Rengtved LundegaardLinea C TrudsøKarina BanasikSøren BrunakSisse Rye Ostrowskinull nullChristian Torp-PedersenOle V PedersenErik SørensenLars Valeur KøberKasper IversenUnnur ThorsteinsdottirGudmundur ThorgeirssonHenrik UllumDaniel F GudbjartssonJonathan D MosleyHilma HólmKári StefánssonHenning BundgaardMorten Salling OlesenPublished in: European heart journal (2022)
This study showed the advantage of using prescription patterns to discover genetic links with ADRs. In total, seven genetic loci that associated with ACEi discontinuation were identified. There was evidence of a strong association between our ADR phenotype and ACEi-associated cough. Taken together, these findings increase insight into the pathophysiological processes that underlie ACEi-associated ADRs.