Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities.
Stacy M Endres-DigheYuelong GuoTamir KaniasMarion LanteriMars StoneBryan SpencerRitchard G CableJoseph E KissSteve KleinmanMark T GladwinDonald J BrambillaPam D'AndreaDarrell J TriulziAlan E MastGrier P PageMichael P Buschnull nullPublished in: Transfusion (2018)
The cohort provides demographic, behavioral, biochemical, and genetic data for a broad range of blood donor studies related to iron metabolism, adverse consequences of iron deficiency, and differential hemolysis (including oxidative and osmotic stress perturbations) during RBC storage. Linkage to recipient outcomes may permit analysis of how donor characteristics affect transfusion efficacy. Repository DNA, plasma, and RBC samples should expand the usefulness of the current data set.
Keyphrases
- red blood cell
- iron deficiency
- electronic health record
- genome wide
- big data
- cardiac surgery
- single molecule
- cell free
- emergency department
- rotator cuff
- type diabetes
- adipose tissue
- gene expression
- data analysis
- acute kidney injury
- dna methylation
- machine learning
- hiv testing
- insulin resistance
- men who have sex with men