Dopamine receptor antagonists induce differentiation of PC-3 human prostate cancer cell-derived cancer stem cell-like cells.
Su In LeeMd Saiful Islam RoneyJong Hyeok ParkJi-Young BaekJooyeon ParkSang Kyum KimSong-Kyu ParkPublished in: The Prostate (2019)
Some dopamine receptor antagonists such as thioridazine can induce differentiation of CSC-like cells by inhibiting phosphorylation of AMPK. Binding to DRD2 or DRD4 might have mediated the action of thioridazine involved in the differentiation of CSC-like cells.