Phylogeny-guided microbiome OTU-specific association test (POST).
Caizhi HuangBenjamin J CallahanMichael C WuShannon T HollowayHayden BrochuWenbin LuXinxia PengJung-Ying TzengPublished in: Microbiome (2022)
Using POST, we show that adaptively leveraging the phylogenetic information can enhance the selection performance of associated microbiome features by improving the overall true-positive and false-positive detection. We developed a user friendly R package POSTm which is freely available on CRAN ( https://CRAN.R-project.org/package=POSTm ). Video Abstract.