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Senomic view of the cell: Senome versus Genome.

Frantisek BaluskaWilliam B Miller
Published in: Communicative & integrative biology (2018)
In the legacy of Thomas Henry Huxley, and his 'epigenetic' philosophy of biology, cells are proposed to represent a trinity of three memory-storing media: Senome, Epigenome, and Genome that together comprise a cell-wide informational architecture. Our current preferential focus on the Genome needs to be complemented by a similar focus on the Epigenome and a here proposed Senome, representing the sum of all the sensory experiences of the cognitive cell and its sensing apparatus. Only then will biology be in a position to embrace the whole complexity of the eukaryotic cell, understanding its true nature which allows the communicative assembly of cells in the form of sentient multicellular organisms.
Keyphrases
  • single cell
  • cell therapy
  • dna methylation
  • induced apoptosis
  • stem cells
  • cell cycle arrest
  • mesenchymal stem cells
  • cell proliferation
  • bone marrow
  • endoplasmic reticulum stress
  • pi k akt