Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics.
Kulkaew SukniamHarsheen K ManaiseKyle PoppReed PoppEmmanuel M GabrielPublished in: Cells (2024)
We aimed to review the molecular characteristics of metastatic melanoma and the role of surgery in metastasectomy for metastatic melanoma. We performed a systematic literature search on PubMed to identify relevant studies focusing on several mutations, including NRAS, BRAF, NF1, MITF, PTEN, TP53, CDKN2A, TERT, TMB, EGFR, and c-KIT. This was performed in the context of metastatic melanoma and the role of metastasectomy in the metastatic melanoma population. A comprehensive review of these molecular characteristics is presented with a focus on their prognosis and role in surgical metastasectomy.
Keyphrases
- minimally invasive
- coronary artery bypass
- small cell lung cancer
- systematic review
- pi k akt
- signaling pathway
- single molecule
- oxidative stress
- cell proliferation
- surgical site infection
- immune response
- nuclear factor
- coronary artery disease
- inflammatory response
- acute coronary syndrome
- metastatic colorectal cancer
- toll like receptor