Variable antiviral activity of islatravir against M184I/V mutant HIV-1 selected during antiretroviral therapy.

Paula C AulicinoSuman SharmaKhanghy TruongVindhya KukunoorKarm GheiSolange Arazi-CaillaudMoira TaiczRosa BolognaAndrea ManganoJason T Kimata

Published in: The Journal of antimicrobial chemotherapy (2024)

Mutations and polymorphisms selected in vivo together with M184V/I depend on the viral genetic context and on ART history, and could affect the efficacy of islatravir once available for use in the clinic.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv infected patients
hiv aids
sars cov
primary care
genome wide
gene expression
copy number
men who have sex with men
south africa