Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing.

Jian Cui Xiaoyun Li Shuhui Deng Chenxing Du Huishou Fan Wenqiang Yan Jingyu Xu Xiaoqing Li Tengteng Yu Shuaishuai Zhang Rui Lv Weiwei Sui Xiaojing Wei Xin Du Lian Xu Shuhua Yi Dehui Zou Tao Cheng Lugui Qiu Xin Gao Gang An

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These data suggest that MM cells could rapidly adapt to induction treatment through transcriptional adaptation, metabolic adaptation, and specialized immune evasion. Targeting therapy-induced resistance mechanisms may help to avert refractory disease in MM.

Keyphrases

single cell
high glucose
diabetic rats
multiple myeloma
induced apoptosis
rna seq
gene expression
drug induced
palliative care
high throughput
stem cells
cell cycle arrest
big data
machine learning
cell proliferation
signaling pathway
stress induced
bioinformatics analysis