Identification of New, Translatable ProtectomiRs against Myocardial Ischemia/Reperfusion Injury and Oxidative Stress: The Role of MMP/Biglycan Signaling Pathways.

Tamara SzabadosArnold MolnárÉva KenyeresKamilla GömöriJudit PipisBence PósaAndrás MakkosBence Agg Zoltán GiriczPéter FerdinandyAnikó GörbePéter Bencsik

Published in: Antioxidants (Basel, Switzerland) (2024)

Our findings highlight 24 miRNAs that potentially regulate cardioprotective therapeutic targets associated with MMPs and BGN in a highly translatable porcine model of acute myocardial infarction.

Keyphrases

ischemia reperfusion injury
acute myocardial infarction
oxidative stress
left ventricular
signaling pathway
induced apoptosis
percutaneous coronary intervention
diabetic rats
dna damage
pi k akt
cell migration
acute coronary syndrome
endoplasmic reticulum stress