PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors.
Kensuke TateishiTaishi NakamuraTareq A JuratliErik A WilliamsYuko MatsushitaShigeta MiyakeMayuko NishiJulie J MillerShilpa S TummalaAlexandria L FinkNina LelicMara V A KoernerYohei MiyakeJo SasameKenji FujimotoTakahiro TanakaRyogo MinamimotoShigeo MatsunagaShigeo MukaiharaTakashi ShutoHiroki TaguchiNaoko UdakaHidetoshi MurataAkihide RyoShoji YamanakaWilliam T CurryDora Dias-SantagataTetsuya YamamotoKoichi IchimuraTracy T BatchelorAndrew S ChiA John IafrateHiroaki WakimotoDaniel P CahillPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Activation of the PI3K/AKT/mTOR pathway is an oncogenic driver and is associated with xenograft formation in oligodendrogliomas. These findings have implications for therapeutic targeting of PI3K/AKT/mTOR pathway activation in progressive oligodendrogliomas.