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Rhodium-catalyzed C-H activation/cyclization of aryl sulfoximines with iodonium ylides towards polycyclic 1,2-benzothiazines.

Gao HuangYujia ShanJin-Tao YuChangduo Pan
Published in: Organic & biomolecular chemistry (2021)
The synthesis of 1,2-benzothiazine derivatives through rhodium-catalyzed C-H activation/cyclization of S-aryl sulfoximines with iodonium ylides was developed for the first time. In this report, C-H and N-H bond functionalization was realized towards a series of tricyclic and tetracyclic sulfoximine derivatives with moderate to excellent yields under simple reaction conditions.
Keyphrases
  • room temperature
  • structure activity relationship
  • high intensity
  • electron transfer