Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages.

Linyu GengJian ZhaoYun DengIvan MolanoXue XuLingxiao XuPhillip RuizQuanzhen LiXuebing FengMiaojia ZhangWenfeng TanDiane L KamenSang-Cheol BaeGary S GilkesonLingyun SunBetty P Tsao

Published in: Annals of the rheumatic diseases (2021)

A lupus causal variant, NCF1-H90, reduces macrophage efferocytosis, enhances Tfh2 responses and promotes autoantibody production and kidney damage in both mice and patients with SLE.

Keyphrases

systemic lupus erythematosus
disease activity
rheumatoid arthritis
oxidative stress
endothelial cells
adipose tissue
high fat diet induced
induced pluripotent stem cells
insulin resistance