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Effects of different aberrations in the CRLF2 gene on the biological characteristics and drug sensitivities of Nalm6 cells.

Min GuYannan JiaMeizhen XuJuan FengZheng TianXiaotong MaMin WangJianxiang WangYingxi XuQing RaoLiangchun HaoYingchang MiWei Yang
Published in: International journal of laboratory hematology (2020)
The overexpression of CRLF2, CRLF2 + IK6, P2RY8-CRLF2 and CRLF2 F232C promotes the proliferation of Nalm6 cells, activates the JAK/STAT signalling pathway and leads to a reduction in sensitivity towards various chemotherapeutic drugs.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • signaling pathway
  • copy number
  • endoplasmic reticulum stress
  • cell proliferation
  • cell death
  • gene expression
  • transcription factor
  • genome wide
  • pi k akt
  • drug induced