Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study.
Liesbet De BusPieter DepuydtJohan SteenSofie A M DhaeseKen De SmetAlexis TabahMurat AkovaMenino Osbert CottaGennaro De PascaleGeorge DimopoulosShigeki FujitaniJose Garnacho-MonteroMarc LeoneJeffrey LipmanMarlies OstermannJosé-Artur PaivaJeroen A SchoutenFredrik SjövallJean François TimsitJason Alexander RobertsJean-Ralph ZaharFarid ZandKapil G ZirpeJan J De Waelenull nullPublished in: Intensive care medicine (2020)
ADE was infrequently applied in critically ill-infected patients. The observational effect estimate on clinical cure suggested no deleterious impact of ADE compared to no-ADE. However, residual confounding is likely.
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