LncRNA CARMN overexpression promotes prognosis and chemosensitivity of triple negative breast cancer via acting as miR143-3p host gene and inhibiting DNA replication.

Xiaonan ShengHuijuan DaiYueyao DuJing PengRui ShaFan YangLiheng ZhouYanping LinShuguang XuYifan WuWenjin YinJinsong Lu

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our results indicated lncRNA CARMN is a predictive biomarker of better prognosis and enhanced cisplatin sensitivity in TNBC. CARMN is the host gene of miR143-3p which downregulates MCM5, causing inhibited DNA replication.

Keyphrases

copy number
genome wide
long non coding rna
genome wide identification
cell proliferation
signaling pathway
long noncoding rna
transcription factor
dna methylation