Association between pre-treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis.
Alex WongMaria RileySongzhu ZhaoJing Gennie WangVince EsguerraMingjia LiGabrielle LopezGregory A OttersonKari KendraCarolyn J PresleyLai WeiDwight H OwenKevin HoPublished in: Cancer immunology, immunotherapy : CII (2023)
Pre-existing interstitial abnormalities on CT chest and reduced TLC were strongly associated with developing ICI-p. Prospective studies are warranted to further explore the role of PFTs as a potential tool for identifying patients at highest risk for developing ICI-p.