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Small Molecule Destabilizer of β-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.

Jung Kyu ChoiHeeyeong ChoByoung-San Moon
Published in: Targeted oncology (2021)
CPD0857 may be a potential drug for treating aggressive CRC carrying mutations that aberrantly activate Wnt/β-catenin and Ras-ERK pathways.
Keyphrases
  • cell proliferation
  • small molecule
  • wild type
  • epithelial mesenchymal transition
  • small cell lung cancer
  • signaling pathway
  • stem cells
  • epidermal growth factor receptor
  • pi k akt
  • drug induced
  • climate change