Patterns of antibody response to SARS-CoV-2 among 1.6 million blood donors: Impact of vaccination, United States December 2020 - June 2021.
Roger Y DoddEdward P NotariJaye P BrodskyGregory A FosterMeng XuPaula SaáSusan L StramerPublished in: The Journal of infectious diseases (2021)
From December 2020 to June 2021, 1,654,487 blood donors were tested for antibodies to SARS-CoV-2 S1 protein and 1,028,547 (62.17%) were reactive. A rapid increase in prevalence was due to vaccination. Among a subset of 1,567,446 donors, 729,771 (46.56%) reported SARS-CoV-2 vaccination, of whom 633,769 (86.84%) were S1-antibody reactive only, in response to vaccination and 68,269 (9.35%) were reactive to both S1 and nucleocapsid, in response to prior infection; the remainder were not reactive to either antibody. Among the 837,675 (53.44%) donors who did not report vaccination, 210,022 (25.07%) had reactivity to both antibodies and 29,446 (3.52%) to S1 only.