Restoration of erectile function by suppression of corporal apoptosis and oxidative stress with losartan in aged rats with erectile dysfunction.

Yi WangYamin WangRong CongYe TianChen ChenYichun WangQijie ZhangXiang ZhouChengjian JiXianghu MengNing-Hong Song

Published in: Andrology (2020)

Our results indicated that administration of losartan not merely restored erectile function, but also significantly prevented corporal apoptosis and oxidative stress in AED by suppressing the Akt/Bad/Bax/caspase-3 and Nrf2/Keap-1 pathways.

Keyphrases

oxidative stress
induced apoptosis
endoplasmic reticulum stress
diabetic rats
dna damage
ischemia reperfusion injury
angiotensin ii
cell death
signaling pathway
cell proliferation
benign prostatic hyperplasia
heat shock