Kidney Function as a Key Driver of the Pharmacokinetic Response to High-Dose L-Carnitine in Septic Shock.
Theodore S JennaroMichael A PuskarichThomas L FlottLaura A McLellanAlan E JonesManjunath P PaiKathleen A StringerPublished in: Pharmacotherapy (2023)
High-dose L-carnitine supplementation is well-described by a two-compartment population PK model in patients with septic shock. Kidney function estimates that leverage cystatin C provided superior model fit. Future investigations into high-dose L-carnitine supplementation should consider baseline metabolic status and dose adjustments based on renal function over a fixed or weight-based dosing paradigm.