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Effect of maternal oxytocin on umbilical venous and arterial blood flows during physiological-based cord clamping in preterm lambs.

Fiona J StenningGraeme R PolglaseArjan B Te PasKelly J CrossleyMartin KluckowAndrew W GillEuan Morrison WallaceErin V McGillickCorinna BinderDouglas A BlankCalum RobertsStuart B Hooper
Published in: PloS one (2021)
We found no evidence that amplification of uterine contractions with oxytocin increase placental transfusion during DCC. Instead they decreased both UA and UV flow and caused a net loss of blood from the lamb. Uterine contractions did, however, have significant cardiovascular effects and reduced systemic and cerebral oxygenation.
Keyphrases
  • low birth weight
  • birth weight
  • gestational age
  • physical activity
  • body mass index
  • acute kidney injury
  • preterm infants
  • sickle cell disease
  • blood brain barrier
  • drug induced