Therapeutic Path to Triple Knockout: Investigating the Pan-inhibitory Mechanisms of AKT, CDK9, and TNKS2 by a novel 2-Phenylquinazolinone derivative in Cancer Therapy- An In-Silico Investigation.
Xylia Q PetersGhazi ElaminAimen AljoundiMohamed Issa AlahmdiNader E Abo-DyaPeter A SidhomAhmed M TawfeekMahmoud A A IbrahimOpeyemi S SoremekunMahmoud E S SolimanPublished in: Current pharmaceutical biotechnology (2023)
The following structural insights provide a starting point for understanding the pan-inhibitory activity of 2-(4-aminophenyl)-7-chloro-3H-quinazolin-4-one. Determining the criticality of the interactions that exist between the pyrimidine ring and catalytic residues could offer insight into the structure-based design of innovative tankyrase-kinase inhibitors with enhanced therapeutic effects.