A water-soluble membrane transporter for biologically relevant cations.

Kylie YangJessica E BolesLisa J WhiteKira L F HiltonHin Yuk LaiYifan LongJennifer R Hiscock Cally J E Haynes

Published in: RSC advances (2022)

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

Keyphrases

water soluble
ionic liquid
primary care
human health
risk assessment