Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis.
Katharine E StottMelanie MoyoAjisa AhmaduCheusisime KajangaEbbie GondweWezzie Chimang'angaMadalitso ChaswekaTshepo B LeemeMooketsi MolefiAwilly ChofleGabriella BidwellJohn ChangaluchaJenny UnsworthAna Jimenez-ValverdeDavid S LawrenceHenry C MwandumbaDavid G LallooThomas S HarrisonJoseph N JarvisWilliam HopeAnne-Grete MärtsonPublished in: The Journal of antimicrobial chemotherapy (2022)
This study provides novel insight into the PK of AmBisome at the population level and the variability therein. Our analysis also serves to highlight the paucity of data available on the pharmacodynamics (PD) of AmBisome and underscores the importance of thorough and detailed PK/PD analysis in the development of novel antifungals, by demonstrating the challenges associated with post hoc PK/PD analysis.