Autologous hematopoietic stem cell transplantation modifies specific aspects of systemic sclerosis-related microvasculopathy.
Maynara Santana-GonçalvesDjúlio Zanin-SilvaÁlvaro Henrique-NetoDaniela A MoraesMarianna Y Kawashima-VasconcelosJoão R Lima-JúniorJuliana B E DiasVinícius BragagnolloJúlia T C de AzevedoDimas T CovasKelen C R MalmegrimLeandra RamalhoMaria Carolina OliveiraPublished in: Therapeutic advances in musculoskeletal disease (2022)
Our results suggest that AHSCT contributes to improvements of the vessel morphology and dermal microvasculopathy, but does not normalize elevated levels of serum vascular markers in SSc patients. Additional vascular therapeutic approaches might contribute to more effectively treat the endothelial injury.