The metabolic and neuroinflammatory changes induced by consuming a cafeteria diet are age-dependent.
Deborah TeixeiraAna Lucia CecconelloWania Aparecida PartataLuciano Stürmer de FragaMaria Flávia Marques RibeiroRenata Padilha GuedesPublished in: Nutritional neuroscience (2017)
The 3- and 18-month-old rats responded differently to a cafeteria diet. Insulin and leptin levels are elevated in young animals fed a cafeteria diet, whereas aged animals are prone to neuroinflammation (indicated by an increase in interleukin-1β levels). A combination of hypercaloric diet and senescence have detrimental effects on the inflammatory response in the brain, which may predispose to neurological diseases.