Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule.
Nori J L SmeetsCarlijn H C LitjensJeroen J M W van den HeuvelHedwig van HovePetra van den BroekFrans G M RusselJan B KoenderinkSaskia N de WildtPublished in: Pharmaceutics (2020)
The affinity of enalaprilat for OAT3 and OAT4 was notably low compared to other substrates. Taking this affinity and clinically relevant plasma concentrations of enalaprilat and other OAT3 substrates into account, we believe that drug-drug interactions on a transporter level do not have a therapeutic consequence and will not require dose adjustments of enalaprilat itself or other OAT3 substrates.
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