Phosphatidic acid promotes the generation of IL-17A producing double-negative T cell by enhancing mTORC1 signaling in lupus.

Wenjing LiXiaojun TangYuanyuan ZhengXuefeng XuNan ZhaoBetty P TsaoXuebing FengLingyun Sun

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

The accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus.

Keyphrases

systemic lupus erythematosus
single cell
cell therapy
disease activity
stem cells
rheumatoid arthritis
mesenchymal stem cells