Allogeneic haematopoietic cell transplants as dynamical systems: influence of early-term immune milieu on long-term T-cell recovery.

Viktoriya ZeliksonRoy SaboMyrna SerranoYounus AqeelSavannah WardTaha Al JuhaishiMay AzizElizabeth KriegerGary SimmonsCatherine RobertsJason ReedGregory BuckAmir Ahmed Toor

Published in: Clinical & translational immunology (2023)

The long-term superior immune recovery in the MMF15 arm, administered GMCSF, is consistent with a disproportionate impact of early interventions in HCT. Modifying the 'immune-milieu' following allogeneic HCT is feasible and may influence long-term T-cell recovery.

Keyphrases

stem cell transplantation
bone marrow
hematopoietic stem cell
physical activity
preterm infants
cell therapy
stem cells
gestational age
signaling pathway
cell death
molecular dynamics